Marking, L. L., Howe, G. E., and Crowther, J. R., 1988, Toxicity of erythromycin,
oxytetracycline, and tetracycline administered to lake trout in water baths, by
injection, or by feeding: The Progressive Fish Culturist, v. 50, no. 4, p. 197-201.

Abstract:

The toxicities of three antibiotics, each administered by three routes at doses up to
five times the  recommended concentrations, were determined in lake trout
(Salvelinus namaycush ). In water bath exposures,  erythromycin phosphate was
considerably less toxic than oxytetracycline hydrochloride (OTC) or tetracycline 
hydrochloride (TC); however, the toxicity of all three antibiotics was low. Injections
of erythromycin produced  no deleterious effects, even at concentrations four times
the standard dose rate. Injections of OTC produced  adverse effects and mortality at
high treatment rates. A water-soluble form of TC was judged unsatisfactory for 
injections because of its low pH (2.5). In feeding studies, the palatability of
erythromycin-treated feed was poor,  but that of OTC- and TC-treated feeds was
acceptable.

Keywords:

erythromycin, oxytetracycline, tetracycline, aquaculture-techniques,
Salvelinus-namaycush, disease- control, prophylaxis, comparative-studies,
antibiotics, toxicity-tests, fish-culture, toxicity, drug-delivery-comparisons