Plakas, S. M., El Said, K. R., and Stehly, G. R., 1994, Furazolidone disposition
after intravascular and oral dosing in the channel catfish: Xenobiotica, v. 24, no.
11, p. 1095-1105.

Abstract

The pharmacokinetics, tissue distribution and excretion of the nitrofuran drug
furazolidone have been examined in the channel catfish. [
super(14)C]Furazolidone was administered by intravascular or oral routes in a
single dosage of 1 mg/kg body weight. A two-compartment pharmacokinetic
model best described parent furazolidone concentrations in the plasma after
intravascular dosing. Elimination of parent compound was extremely rapid, with a
terminal half-life of 0.27 h and total body clearance of 1901 ml/h/kg. After oral
dosing, furazolidone concentrations in the plasma were highest at 1 h and were
below the limit of determination (< 20 ng/ml) at 5 h. The oral bioavailability of
parent furazolidone administered in solution was 58%, compared with 28% in a
feed mixture. Concentrations of furazolidone and its metabolites were highest in
the excretory tissues and lowest in the muscle after oral dosing. Parent
furazolidone comprised 10% of the total super(14)C in the muscle at 8 h and was
not detectable (< 1 ng/g) at 24 h; total super(14)C concentrations declined from
274 to 59 ng furazolidone equiv./g between 8 and 168 h. Non-extractable (bound)
residues comprised 18% of total super(14)C in muscle at 8 h and 33% at 168 h.
Renal excretion was the primary route of elimination of super(14)C residues and
accounted for nearly 55% of the oral dose.
Keywords

furazolidone-, Ictalurus-punctatus, antimicrobial-agents, antibiotics-, fish-culture,
fish-diseases, disease- control, pharmacology-, human-food, food-fish, drugs-,
public-health